Radiation Biology of Medical Imaging by unknow

Author:unknow
Language: eng
Format: epub
Publisher: John Wiley & Sons, Incorporated
Published: 2013-12-17T05:00:00+00:00

Cancer Cells Ignore Antigrowth Signals at Boundaries

At the surface of the liver, the cells are in contact with nonliver cells. The membranes of the border liver cells send antigrowth signals to their nucleus stopping further growth. In cancer cells, the antigrowth signals from the cells at the border are ignored or suppressed, and the cancer cells continue to spread beyond the border.

Cancer Cells Generate Their Own Blood Supply (Angiogenesis)

The ability of cancer cells to generate their own blood supply is a crucial step in their progression. Without the ability to create their own independent blood supply, they would remain just a localized clump of cells smaller than a sesame seed. Tumors depending on an existing blood vessel are limited to about a 100-µm radius, which is the diffusion distance of oxygen, nutrients, and waste products. The development of independent blood vessels is signaled by the release of vascular endothelial growth factor (VEGF), which stimulates the growth of new blood vessels. One of the current areas of cancer research is the use of VEGF suppressors to inhibit the growth of cancer. However, VEGF is needed by the body for wound healing and injury repair, so completely shutting down VEGF is undesirable.

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